If you use CIP3/4 PPF file to preset ink keys from CtP RIP, and your first pull is long enough, >100 shts, then YES, you should scan the sheet for color/density and make corrective moves.
Register and color moves should be done in parallel, simultaneously.
The goal is to use the least amount of time/labor and materials/paper to finish the makeready (MR) and get the OK to start running production.