How old are the dampening rollers? 4 years, way too old. 3 years? Replace. 2 years? You should replace them if you can't run for a couple of hours.
If whoever pays the bills doesn't know, replace them.
You have a stripe larger than specified-you might have the wrong roller in that position.
#3 is the largest, at the bottom when opening up the delivery end safety gate. #2 is the smallest.
Setting roller nips should be simple. Fat stripe, thin stripe, the two 3302's I run will run. Btw set #3 stripe to plate very light.
I doubt that fountain solution or ink is your problem. I have literally and for years used ink scavenged from out of business shops 10, 15+ years old. My employer changes ink suppliers when they see a good price. Currently using Wickoff(?) or Epple. No difference, misc inks of every flavor any day. Wax free, "made for plastic" (non porus or foil surface), "for uncoated only".
Two things I would stress. Decent dampener rollers and not running slow. The other guy who runs these presses (he primarily runs the 4 color) has to clean dampeners every hour but he won't run past 6m iph. I insist on fewer clean ups and try to run 7m iph minimum.