We run a lot of low coverage Variable data so we tend to get 600K-1200K+ on our PR belts usually. But I would imagine if you run mostly high coverage sheets you will greatly decrease PR life.
The way to ensure maximum PR belt life is when you do your maintenance prior to changing the belt. Clean all the backer bars and drive rollers thoroughly. Clean out the cleaner housing and replace the SPOTS blade. And every 3 belt changes or so, replace the cleaner brushes and flicker bars. The SPOTS blade will wear according to the shape of the current PR Belt, so when you change the PR Belt without replacing the SPOTS blade, you could potentially cause uneven cleaning/wear, or so I'm told. Likely those process direction streaks you are referring to are caused by buildup of ozone on the underside of the PR Belt.