i run a 52-2 colour heidelberg gto an thats the biggest we have got so we do all our 4 col process work on there. it has its setbacks but at the moment i prefer it because you dont have 4 cols coming out at you at one time. you can concentrate on each colour and as long as your fit an reg is spot on you shouldnt have a problem, this is done easily by checking the lay. but if you are looking to do it quick an want to see how its going to come out straight away get a 4 colour!! ..